Pharmaceutical Water Treatment

pharmaceutical water treatmentPharmaceutical water treatment requires removing contaminents from municipal drinking water to meet USP standards. There are two basic types of pharmaceutical water; water for topical use or cleaning (sterle purified water, or PW), or water for injection(WFI) which includes sterile water for irrigation and most sterile water for inhalation.

For PW, USP guidelines require a conductivity limit of 0.6–4.7 µS/cm, a total organic carbon or total oxidizable carbon (TOC) limit of 500 ppb (µg/L), and a bacteria-count limit of 100 cfu/mL.

For WFI, the USP guidelines require a conductivity limit of 0.6–4.7 µS/cm, a TOC limit of 500 ppb (µg/L), an endotoxin limit of 0.25 endotoxin units/mL and a bacteria-count limit of 10 cfu/100 mL.

The main difference between PW and WFI is the amount of bacterial contamination allowed, measured by colony count and by endotoxin level.

Every water treatment plant is unique, but may include a combination of these methods: